Inhibition of Delayed-Type Hypersensitivity by Cucurbitacin R Through the Curbing of Lymphocyte Proliferation and Cytokine Expression by Means of NFAT Translocation to the Nucleus
نویسندگان
چکیده
Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Spain (J.M.E.,M.C.R., R.M.G., S.M., J.L.R.), Departament de Patologia, Facultat de Medicina, Universitat de València, Spain (M.C.-N.), and Department of Pharmaceutical Biology and Biotechnology, Albert-Ludwigs-University Freiburg, Germany (I.M.). JPET Fast Forward. Published on October 21, 2009 as DOI:10.1124/jpet.109.159327
منابع مشابه
Inhibition of delayed-type hypersensitivity by Cucurbitacin R through the curbing of lymphocyte proliferation and cytokine expression by means of nuclear factor AT translocation to the nucleus.
Cucurbitacin R is known to exhibit an anti-inflammatory effect in different experimental models of inflammation. In this article, we outline the effect of cucurbitacin R on T lymphocyte proliferation, cytokine production, and nuclear factor activation, as well as its influence on various experimental models of delayed-type hypersensitivity (DTH) in mice. Cucurbitacin R reduced the proliferation...
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We have studied the effects of dihydrocucurbitacin B, a triterpene isolated from Cayaponia tayuya roots, on different models of delayed type hypersensitivity (DTH) in mice, as well as on T-lymphocyte proliferation and the mediators involved. In experiments with mice, dihydrocucurbitacin B inhibited the inflammatory reactions induced by oxazolone, dinitrofluorobenzene, and sheep red blood cells,...
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BACKGROUND AND PURPOSE Cucurbitacin R, a natural anti-inflammatory product, has been shown to exhibit activity against both adjuvant-induced arthritis and delayed-type hypersensitivity reactions induced by various agents. Previous studies have demonstrated that the effects of cucurbitacin R stem from its inhibition of both cytokine production and lymphocyte proliferation. EXPERIMENTAL APPROAC...
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تاریخ انتشار 2009